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Laboratory diagnosis of thyroid hormones in clinical medicine
KAVICKÁ, Andrea
Diseases of thyroid gland are the most common endocrine disorders after diabetes mellitus. Laboratory diagnostics has irreplaceable role in the diagnostics of thyroid gland disorders. The first part describes the various thyroid diseases, their causes, symptoms, treatment and diagnostics. The second part this work includes meaning and the principle of individual parameters examinated for monitoring of thyroid gland disorders. Examination of the parameters of the thyroid gland is a very busy immunoassay methods. Methods of the thyroid gland used for determining the functional status of the thyroid gland. Inform us about the etiology, monitoring therapy and based on that choose treatment procedure. Thyreotropin is a very sensitive and specific marker for evaluating the function of thyroid gland and simultaneously appropriate for early detection or exclusion of thyroid disorders. In the case of TSH out of reference limit we set further examination fT4, rarely fT3. TSH and free fraction´s of thyroxine and trijodthyronine performed on the analyzer Roche Modular E, which uses methods ECLIA. Detection of antibodies were determined by using analyzer from Siemens company Immulite XPi, which is based on chemiluminescent immunometric analysis. Examination of anti-Tg and anti-TPO tell us a lot about the etiology of testing in the case of autoimmune disease. I investigated 830 patients, 299 men and 531 women, where on the based TSH out of reference limit diagnostic hypothyroidism and hyperthyroidism. My research, I am allowed to supplement the expertise of the doctors who requested the examination of thyroid hormones In the end this work is graphically represented frequency determination of hormones and thyroid autoantibodies for the year 2013 in our laboratory.
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